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PDF – khaki-shadows.pdf (10K)… Download Full PDF on akartvnafigures.blogspot.com…. Khaki shadows by k m arif pdf free 57.Historical data during the last 18 years indicate that the number of patients with chronic severe asthma is substantially increasing. It is important to understand the factors associated with poor outcomes in this cohort in order to develop targeted treatments. We will evaluate novel biomarkers of inflammation and mechanical injury as correlates of clinical outcome in a cohort of poorly controlled patients with severe asthma. We will also conduct comparative studies of novel biomarkers in two other populations. First, we will compare the potential pathophysiologic and clinical correlates of the acute early response to mild versus severe asthma in patients recruited from the Emergency Department. We will define the early response to mild versus severe asthma with measurements of airway responses to common triggers (methacholine, histamine, and exercise). These tests will be performed at the ED visit and immediately after an acute exacerbation, in order to obtain clinically-validated correlates of the acute early response. We have developed cell-based assays to evaluate the effect of ASM cell product deposition on the fibroblast proliferation index in culture. We will also evaluate histopathology and the quantity of ASM cell product deposition on biopsied biopsies obtained from patients with severe asthma who are undergoing lung transplantation. We will conduct a retrospective study of a large referral population of patients with severe asthma in order to determine the importance of the severity of airway disease and/or corticosteroid dosing on the occurrence of asthmatic reactions in patients with severe asthma. For these studies we will determine the frequency of reactivity to commonly administered medications and the clinical outcome of these reactions. Finally, we will conduct a prospective study of patients with newly diagnosed asthma to define the effectiveness and safety of an inhaled corticosteroid with an extended-release formulation. We will compare the effectiveness and safety of two doses of inhaled budesonide/formoterol to placebo in a 24 week, multi-center, double-blind, randomized clinical trial of 520 patients. This project is directly relevant
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