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Background
==========
New markers of cartilage metabolism are needed for the diagnosis and treatment of osteoarthritis. This study aims to correlate biochemical markers to the severity of joint inflammation in the presence of RA.
Methods
=======
Synovial fluid (SF) was taken aseptically from 64 patients affected with RA and 15 synovitis of the knee, the OA group. SF proteins and cytokines were measured by enzyme-linked immunosorbent assay (ELISA). The data was analyzed using SPSS®. Kruskal-Wallis-test and Spearman correlation test were used for statistical analysis.
Results
=======
The levels of IL-1α and ß in SF were significantly higher in the RA group compared to OA. The differences in MMP-3, IL-6 and IL-1α between the OA and RA were not statistically significant. The Spearman correlation between markers of cartilage degradation and cytokines in RA showed that TNFα (r = 0.72 p \#pragma once
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